Center for Infectious Disease Research

Dr. Wu published a recent invited review article about HIV preintegration transcription and host antagonism.

Dr. Wu published a recent invited review article about HIV preintegration transcription and host antagonism.

The article gives the most comprehensive review of the subject in the past 20 years. https://pubmed.ncbi.nlm.nih.gov/37345240/

Dr. Yuntao Wu is a leading expert on HIV preintegration transcription. He discovered the synthesis of a functional Nef protein prior to HIV integration (Wu and Marsh, 2001, Science, 293:1503). 

This image below summarizes the main points covered in this review.

Retrovirus integration is an obligatory step for the viral life cycle. However, large amounts of unintegrated DNA (uDNA) accumulate during HIV infection. HIV preintergration transcription has been found to occur at low levels from a large population of uDNA even in the presence of host epigenetic silencing mechanisms. This review article summarizes previous studies, and discusses critical questions that await to be answered in the future.
The author Yuntao Wu, is a leading expert in the field of HIV preintergration transcription, and has published extensively in the area.