Center for Infectious Disease Research

The van Hoek lab has just published a paper describing the computational design of new antimicrobial peptides (AMPs) with activity against multi-drug resistant (MDR) Acinetobacter baumannii

This picture shows a field-emission scanning electron microscopy image of MDR A. baumannii AB5075 cells treated with HRZN-15 peptide.
Blebs can be seen on the bacterial membrane.

Fahad Alsaab, a current PhD student in Biosciences (MID concentration) and Shravani Bobde (a graduate of the same program) worked together to design and test a set of new peptides called HRZN, as in “horizon”, designed to be effective against MDR A. baumannii. The most active peptide killed these wound-infecting bacteria with a MIC of 4 ug/ml.

Additional authors include Scott N. Dean, another former member of the van Hoek Lab and graduate of the PhD Biosciences program at GMU and Gabriel Ascoli, a summer ASSIP student who worked with Fahad.

The paper was published in the journal Antibiotics (IF 4.8). 

https://www.mdpi.com/2079-6382/12/9/1396